In this Community Call, we discussed: 

• Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension
• Single-Cell Analysis Reveals Distinct Immune and Smooth Muscle Cell Populations that Contribute to Chronic Thromboembolic Pulmonary Hypertension

'Inflamed lung' is part of the Inflammation and Infection Virtual Symposium series by the iPVD, a global education programme that highlights top-notch research on inflammation and infectious PVD. 

'The endothelium' is part of the Inflammation and Infection Virtual Symposium series by the iPVD, a global education programme that highlights top-notch research on inflammation and infectious PVD. 

In this Community Call, we discussed: 

• G9a/GLP Targeting Ameliorates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension
• Right Ventricular Maladaptation to Pressure Overload in Fischer Rats is Associated with Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics
• Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression

In this Community Call, we discussed: 

• Validity of echocardiographic tricuspid regurgitation gradient to screen for new definition of pulmonary hypertension
• Pulmonary Arterial Hypertension Patients Have a Proinflammatory Gut Microbiome and Altered Circulating Microbial Metabolites