The notch receptors: multi-regulators of PAH development

Various erythropoietic abnormalities are highly prevalent among patients with pulmonary arterial hypertension (PAH) and associated with worse disease severity. Given the poorly understood yet important roles of dysregulated erythropoiesis and iron metabolism in PAH, we sought to further characterize the hematologic and iron profiles in PAH and their relationship to PAH severity.

A blood test identifying patients at increased risk of pulmonary hypertension (PH) could streamline the investigative pathway...

• Health and wearables: Is this the dawn of a new age for cardiovascular medicine? Martin Cowie
• Professor Sheila Glennis Haworth Memorial Lecture - Translational Research on PAH, Jason Yuan 
• Biomarker Analysis of the PULSAR Study: An Ongoing Phase 2, Double-Blind, Placebo-Controlled, Randomized Study to Compare the Efficacy and Safety of Sotatercept (ACE-011) Versus Placebo When Added to Standard of Care for the Treatment of PAH, Marc Humbert
• Switching from PDE5i to riociguat in patients with PAH: The REPLACE study, Raymond Benza
• A diagnostic miRNA signature for PAH using a consensus machine learning approach (Rupert Swift Award 2021), Niamh Errington