Plasma NEDD9 is increased following SARS-CoV-2 infection and associates with indices of pulmonary vascular dysfunction

18 March 2024

George A. Alba, Iris Y. Zhou, Molly Mascia, Michael Magaletta, Jehan W. Alladina, Francesca L. Giacona, Leo C. Ginns, Peter Caravan, Bradley A. Maron, Sydney B. Montesi

https://doi.org/10.1002/pul2.12356

Abstract

Compared to healthy volunteers, participants with post-acute sequelae of SARS-CoV-2 infection (PASC) demonstrated increased plasma levels of the prothrombotic protein NEDD9, which associated inversely with indices of pulmonary vascular function. This suggests persistent pulmonary vascular dysfunction may play a role in the pathobiology of PASC.

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