Approach to Lung Transplantation in Pulmonary Arterial Hypertension: A Delphi Consensus on Behalf of the Transplant Task Force of the Pulmonary Vascular Research Institute
Nicholas A. Kolaitis, Hayley Barnes, Deborah J. Levine, Howard Castillo, Selim M. Arcasoy, Matthew Bacchetta, Luke Benvenuto, Erika Berman-Rosenzweig, Marisa Cevasco, Caitlin T. Demarest, Celine Dewachter, Michiel E. Erasmus, Allan R. Glanville, John Granton, Shaf Keshavjee, Vikramjit Khangoora, Sheila Krishnan, Olaf Mercier, Andrea N. Miltiades, David Montani, Edward Murphy, Ivan Robbins, Franck F. Rahaghi, Sahar A. Saddoughi, Laurent Savale, Marc A. Simon, Jean-Luc Vachiery, Corey E. Ventetuolo, Helen M. Whitford, Reda E. Girgis
https://doi.org/10.1002/pul2.70088
Abstract
Lung transplantation is indicated for selected patients with advanced pulmonary arterial hypertension (PAH). We used a modified Delphi process to develop recommendations on care of patients with PAH undergoing lung transplantation. This Delphi panel was recruited from the Pulmonary Vascular Research Institute's Innovative Drug Discovery Initiative - Lung Transplantation Workstream, consisting of clinical and research experts in PAH and lung transplantation. In this process, 29 panelists were given open-ended questions, querying topics related to lung transplantation in PAH. A steering group converted the responses into discrete statements. Panelists then rated agreement using a Likert scale in two further survey rounds: −5 (strongly disagree) to 5 (strongly agree). Consensus was defined as mean ≥ 2.5 or ≤ −2.5, with a standard deviation not crossing zero. Consensus was reached on 141 of 223 statements. Notable areas of consensus were for early discussions about transplantation, and agreement with previously published referral and listing criteria. There was agreement that lung transplantation could be offered in sick candidates, including those with concurrent renal or hepatic insufficiency. Bilateral lung transplantation was considered the procedure of choice for most patients, with rare indications for heart-lung transplantation. Consensus on bridging strategies included use of veno-arterial extracorporeal membrane oxygenation and preemptive awake cannulation in those with severe right ventricular dysfunction. Consensus was also achieved on intraoperative use of invasive hemodynamic monitoring, and prolonged postoperative circulatory support guided by hemodynamic response and echocardiography. Patients with PAH undergoing transplantation require specialized management, which differs somewhat from other candidates.