Biology behind the PAH - HHT overlap

Presented at Genetics-inspired Therapeutics for PH by Wei Li, University Of Cambridge

Summary

This presentation delves into the intricate biological connections between Pulmonary Arterial Hypertension (PAH) and Hereditary Hemorrhagic Telangiectasia (HHT). It highlights shared genetic pathways, particularly focusing on the TGF-beta signaling family and key genes like BMP9, ALK1, and endoglin. The research explores how endoglin influences BMP9 signaling and its potential role in mediating crosstalk between BMP and TGF-beta pathways, offering insights into novel therapeutic targets.

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