Overview of Genetics in PAH & HHT

Presented at Genetics-inspired Therapeutics for PH by Richard Trembath, King's College London

Summary

Richard Trembath explores the critical role of human genetics in understanding Pulmonary Arterial Hypertension (PAH) and Hereditary Hemorrhagic Telangiectasia (HHT). He details how advancements in genome sequencing have revolutionised gene discovery and therapeutic development, emphasising the importance of distinguishing correlation from causation. The presentation highlights genetic variations and their impact on drug target selection, leading to improved therapeutic success rates.

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