Sotatercept - deep phenotyping the cardiac response

Presented at Genetics-inspired Therapeutics for PH by Khodr Tello, Justus-Liebig-Universität Gießen

Summary

This presentation delves into the complex response of the right ventricle to pulmonary hypertension and the impact of sotatercept. It explores advanced phenotyping techniques beyond traditional measurements to understand RV adaptation and failure. The research highlights a multicenter project examining sotatercept's effects on RV hemodynamics, contractility, and remodeling, revealing varied patient responses and potential mechanisms.

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