Keynote II: The role of mutations in epigenetic regulator genes in inflammation & PAH

Presented at PVRI 2026 Congress by Stephen Archer, Queen's University

Summary

The session explores the genetics and epigenetics of pulmonary hypertension, focusing on gene methylation and the roles of genes like DNMT3A and TET2. It discusses somatic mutations, challenges in identifying genetic causes, and potential therapies targeting inflammation. The importance of Taten Brown Reon syndrome, phenotyping, and the active community around it are highlighted, along with the need for further research and clinical trials in understanding the disease.
 

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