Endothelial dysfunction studies in an ovine Glenn Model

Presented at PVRI 2026 Congress by Jeffrey Fineman, University of California

Summary

Endothelial dysfunction in single ventricle heart disease is examined, focusing on its mechanisms and implications for patient outcomes. The discussion covers the economic burden on healthcare, the effects of non-pulsatile flow, and the relationship between endothelial dysfunction and factors like exercise intolerance and inflammation. Future research aims to validate these findings in human samples and explore potential treatments.

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