Research with IPCs from different genetic variants

Presented at PVRI 2026 Congress by Marlene Rabinovitch, Stanford University

Summary

Marlene Rabinovitch highlights a collaboration focused on studying blood from PH patients. The research aims to differentiate blood into induced pluripotent stem cells (iPSCs) to explore mechanisms and therapies. iPSCs mimic native pulmonary arterial cells, aiding in high-throughput testing of novel therapies, including gene therapies. The study investigates mutations in genes like BPR2 and TBX4, revealing differences in cell behaviour and proliferation, and seeks to identify therapeutic targets.

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