Genomic determinants of therapy response in pulmonary veno-occlusive disease: insights from whole-genome sequencing & GWAS

Presented at PVRI 2026 Congress by Natalia Gallego-Zazo, Instituto De Genética Médica Y Molecular

Summary

Preliminary results reveal genomic determinants that influence treatment responses in pulmonary occlusive disease. The study identifies candidate genes and highlights the variability in treatment effects, particularly noting that many patients experience pulmonary edema. Collaborations with registries aim to enhance predictions of treatment responses using genetic data. Whole genome sequencing focuses on integrin signalling pathways, while future research seeks to validate findings and standardise clinical interventions.

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