RUPERT SWIFT AWARD LECTURE: Pro-Inflammatory Epicardial Adipose Tissue as a Key Mediator of Right Ventricle Failure in Pulmonary Arterial Hypertension

Presented at PVRI 2026 Congress by Manon Mougin, IUCPQ

Summary

Epicardial adipose tissue (EAT) plays a significant role in PAH by correlating with right ventricular dysfunction. EAT shifts from a protective to a pro-inflammatory state, affecting myocardial integrity. Cytokines like IL-17 from EAT contribute to cardiac dysfunction. The study also examines extracellular vesicles in EAT and their involvement in inflammation, highlighting the complex relationship between EAT and cardiac health in PAH.

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