In this Community Call, we discussed:

• Digital spatial profiling identifies distinct molecular signatures of vascular lesions in PAH
• Phosphodiesterase-5 inhibitor treatment is associated with improved survival in pulmonary hypertension associated with COPD in the PVRI GoDeep meta-registry

In this Community Call, we discussed:

• Inhaled treprostinil in pulmonary hypertension associated with COPD: PERFECT study results
• Pharmacological Gq inhibition induces strong pulmonary vasorelaxation and reverses pulmonary hypertension

In this Community Call, we discussed: 

• Characteristics and outcomes of patients developing pulmonary hypertension associated with proteasome inhibitors
• Ultrasound neuromodulation of an anti-inflammatory pathway at the spleen improves experimental pulmonary hypertension

In this Community Call, we discussed: 

• Implications of mean pulmonary arterial wedge pressure trajectories in PAH
• Myeloid cell derived IL1β contributes to PH in HFpEF
• Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension

In this Community Call, we discussed: 

• Clinical correlates of a nonplexiform vasculopathy in patients with a diagnosis of idiopathic PAH
• The digital 1-minute walk test: a new patient-centered cardiorespiratory endpoint

In this Community Call, we discussed: 

• RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension 
• Compartment-specific remodeling patterns in end-stage chronic obstructive pulmonary disease with and without severe pulmonary hypertension

In this Community Call, we discussed: 

• Pericytes contribute to pulmonary vascular remodeling via HIF2α signaling 
• Advanced hemodynamic and cluster analysis for identifying novel RV function subphenotypes in patients with pulmonary hypertension

In this Community Call, we discussed: 

• Transcriptional profiles of pulmonary artery endothelial cells in pulmonary hypertension
• Shedding light on latent pulmonary vascular disease in heart failure with preserved ejection fraction

In this Community Call, we discussed:

• Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension
• Effects of sotatercept on haemodynamics and right heart function: analysis of the STELLAR trial
• Impact on Pulmonary Hypertension Hemodynamic Classification Based on the Methodology Used to Measure Pulmonary Artery Wedge Pressure and Cardiac Output

In this Community Call, we discussed: 

• Targeting Wnt-ß-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling
• Win Statistics in PAH Clinical Trials
• Evaluation of a digital health system (PAHcare™) for routine care of patients with pulmonary arterial hypertension: The CBS-PAH study protocol