Beyond the heart and lung: inter-organ cross-talks in PH

Presented at PVRI 2026 Congress by Kurt Prins, Medical University of South Carolina

Summary

Metabolic crosstalk plays a crucial role in organ dysfunction, especially in the liver and kidney of patients with PAH. Liver function is vital for metabolism, and hepatic impairments can negatively affect patient outcomes. The kidney also influences glucose homeostasis and amino acid metabolism, with renal dysfunction leading to worse outcomes in PAH. Recent studies, including RNA sequencing data, reveal the intricate relationship between liver function and metabolic patterns in these patients.

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