KEYNOTE: Mitochondrial & metabolic modulators for PH: opportunities & challenges

Presented at PVRI 2026 Congress by Anna Hemnes, Vanderbilt University Medical Center

Summary

Mitochondrial and metabolic modulators are essential in understanding PH. Research emphasises the role of metabolism, particularly insulin resistance and glucose homeostasis. Metabolic interventions, such as exercise and medications like metformin, show promise in improving patient outcomes. The exploration of fatty acid oxidation inhibitors and carnitine supplementation highlights ongoing challenges in trial design. Future research seeks to clarify the obesity paradox and enhance treatment strategies.

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