Platelet activation & macrophage recruitment drive vascular dysfunction in a murine model of sickle cell PH

Presented at PVRI 2026 Congress by Daniel Colon Hidalgo, University of Colorado

Summary

Daniel explores his research on sickle cell-related PH, focusing on the absence of specific treatments and the impact of platelet dysfunction. He explains the disease's etiology, including haemolysis and hypoxia, and their influence on platelet activation and vascular remodelling. Findings on platelet activation, macrophage roles, and potential therapeutic interventions are presented, along with insights into platelet interactions and treatment strategies.

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