Sotatercept impairs right ventricular function: insights from multi-center preclinical studies

Presented at PVRI 2026 Congress by Sarah-Eve Lemay, Laval University

Summary

The study evaluates cept's effects on patients with PH, focusing on cardiac function, contractility, and mass reduction. Various models and cohorts confirm findings through histological and omic analyses. Results indicate that cept does not enhance right ventricular function and may cause iron accumulation, affecting cardiac health. Further investigation into the drug's long-term effects and the complexities of right ventricular contractility is necessary.

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