In this Community Call, we discussed:

• Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension
• Effects of sotatercept on haemodynamics and right heart function: analysis of the STELLAR trial
• Impact on Pulmonary Hypertension Hemodynamic Classification Based on the Methodology Used to Measure Pulmonary Artery Wedge Pressure and Cardiac Output

In this Community Call, we discussed: 

• Targeting Wnt-ß-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling
• Win Statistics in PAH Clinical Trials
• Evaluation of a digital health system (PAHcare™) for routine care of patients with pulmonary arterial hypertension: The CBS-PAH study protocol

In this Community Call, we discussed: 

• Pathogenesis, clinical features, and phenotypes of pulmonary hypertension associated with interstitial lung disease: A consensus statement from the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative - Group 3 Pulmonary Hypertension
• Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease

In this Community Call, we discussed:

• Wnt7a deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension
• Is low-risk status a surrogate outcome in pulmonary arterial hypertension? An analysis of three randomised trials

In this Community Call, we discussed: 

• Elevated Pulmonary Arterial Compliance Is Associated with Survival in Pulmonary Hypertension: Results from a Novel Network Medicine Analysis
• SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension
• The UPHILL study: A nutrition and lifestyle intervention to improve quality of life for patients with pulmonary arterial hypertension

In this Community Call, we discussed: 

• Maternal outcomes among pregnant women with congenital heart disease–associated pulmonary hypertension
• Proline and glucose metabolic reprogramming supports vascular endothelial and medial biomass in pulmonary arterial hypertension

In this Community Call, we discussed: 

• Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension
• Single-Cell Analysis Reveals Distinct Immune and Smooth Muscle Cell Populations that Contribute to Chronic Thromboembolic Pulmonary Hypertension

In this Community Call, we discussed: 

• G9a/GLP Targeting Ameliorates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension
• Right Ventricular Maladaptation to Pressure Overload in Fischer Rats is Associated with Profound Deficiency in Adenylate Kinase 1 and Impaired Ventricular Energetics
• Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression

In this Community Call, we discussed: 

• Validity of echocardiographic tricuspid regurgitation gradient to screen for new definition of pulmonary hypertension
• Pulmonary Arterial Hypertension Patients Have a Proinflammatory Gut Microbiome and Altered Circulating Microbial Metabolites