Pulmonary hypertension associated with interstitial lung disease (PH-ILD) is one of the deadliest pulmonary conditions and is associated with poor survival and high morbidity (1). The disease is characterized by abnormalities in both the lung interstitium and pulmonary vasculature, which has made finding a treatment challenging (2, 3)...

Webinar presentations: Age-dependent prevalence of PH in the general population, Harm Jan Bogaard, Senescence mechanisms and pulmonary vascular aging, Serge Adnot, Metabolic Syndrome and obesity leads to age-related PH, Imad Al Ghouleh, Genetics and epigenetics in age-related PH, Stephen Archer, Right heart catheterization is underused in elderly patients suspected of pulmonary hypertension, Samara Jansen

Reversal of PH by whole bone marrow transplantation in BMPR2 deficient mice, James West, Bone marrow dependency of cigarette smoke-induced PH versus emphysema, Norbert Weissmann, Homologous bone marrow transplantation prevents the development of PAH in patients with severe scleroderma, Jason Weatherald, Role of bone marrow in the right ventricle remodelling, Gaurav Choudhary

Pulmonary hypertension (PH) is a multifactorial chronic pulmonary disease. During the past decade, various pathophysiological pathways eventually leading to progressive pulmonary vascular remodelling have been detected...

Webinar presentations: Ardeschir Ghofrani (PRO) vs Hiromi Matsubara (CON) on Riociguat should be given to all CTEPH patients, regardless of timing of PEA/BPA, Systematic follow-up of patients following acute pulmonary embolism is associated with an increased incidence of CTEPH and less severe disease, Charlotte Durrington, Women and CTEPH: The special meaning of BPA, Alejandro Cruz-Utrilla, G protein-coupled receptor expression from single cell RNA sequencing in CTEPH, Gayathri Viswanathan, Study of the antifibrotic action of JAK inhibitors for the prevention and treatment of CTEPH, Andrei Karpov, Unilateral chronic thromboembolic pulmonary disease: Do they benefit from surgery? Farid Rashidi

Webinar presentations

• Looking beyond the hype: Applied AI and machine learning in translational medicine, Dennis Wang
• Computational network pharmacology in cardiovascular disease – leveraging big data, Joseph Loscalzo
• Utilizing artificial intelligence to screen and diagnose iPAH, David Kiely
• Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood, Sokratis Kariotis
• Transcriptomic characterization of Pulmonary arterial hypertension on pathway level, Yajing Ji 

• When should a PH patient be considered for lung transplant? John Granton 
• Atrial septum defect creation or mechanical support for end-stage PAH Erika Rosenzweig 
• Lung and Heart-lung Transplant in 2021 – how well do PAH patients do? Eugene Golts
• Pluripotent stem cell-based approaches and the future of artificial lungs Ulrich Martin
• Timing and extent of ventricular reverse remodelling after lung transplant for PH Ryan Tedford 

An article from the PVRI IDDI Emerging Technologies Working Group by Peter Fernandes

• MicroRNAs and IncRNAs in right heart hypertrophy and failure Francois Potus
• LncRNA as biomarkers/therapeutic agents for pulmonary diseases - prospective view Stephen Chen 
• Epigenomics in pulmonary vascular remodelling Soni Savai-Pullamsetti 
• Multiomic tools for single cell analysis Herbert Schiller
• Proteomics: From discovery research toward the clinic - novel AI perspectives? Christopher Rhodes 

Pulmonary hypertension (PH) is a frequent finding in advanced COPD. Usually pulmonary pressure is only mildly elevated, but a subgroup of patients develops severe PH, arbitrarily defined as mean pulmonary pressure (mPAP) ≥35 mmHg)...