Therapies in the real world - how much do we diverge from trial populations?

Presented at PVRI 2026 Congress by Mark Toshner, University of Cambridge

Summary

This session reveals an evidence gap in drug development for PH, focusing on the disparity between clinical trial populations and real-world patients. Analysis of two datasets shows that many real-world patients do not meet trial eligibility criteria, raising concerns about the relevance of trial results. Despite this, outcomes for trial-ineligible patients are similar to those eligible, highlighting the need for better understanding in future trial designs.

Generated with AI, edited by PVRI