Webinar presentations

• Looking beyond the hype: Applied AI and machine learning in translational medicine, Dennis Wang
• Computational network pharmacology in cardiovascular disease – leveraging big data, Joseph Loscalzo
• Utilizing artificial intelligence to screen and diagnose iPAH, David Kiely
• Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood, Sokratis Kariotis
• Transcriptomic characterization of Pulmonary arterial hypertension on pathway level, Yajing Ji 

• When should a PH patient be considered for lung transplant? John Granton 
• Atrial septum defect creation or mechanical support for end-stage PAH Erika Rosenzweig 
• Lung and Heart-lung Transplant in 2021 – how well do PAH patients do? Eugene Golts
• Pluripotent stem cell-based approaches and the future of artificial lungs Ulrich Martin
• Timing and extent of ventricular reverse remodelling after lung transplant for PH Ryan Tedford 

An article from the PVRI IDDI Emerging Technologies Working Group by Peter Fernandes

• MicroRNAs and IncRNAs in right heart hypertrophy and failure Francois Potus
• LncRNA as biomarkers/therapeutic agents for pulmonary diseases - prospective view Stephen Chen 
• Epigenomics in pulmonary vascular remodelling Soni Savai-Pullamsetti 
• Multiomic tools for single cell analysis Herbert Schiller
• Proteomics: From discovery research toward the clinic - novel AI perspectives? Christopher Rhodes 

Pulmonary hypertension (PH) is a frequent finding in advanced COPD. Usually pulmonary pressure is only mildly elevated, but a subgroup of patients develops severe PH, arbitrarily defined as mean pulmonary pressure (mPAP) ≥35 mmHg)...

• Role of notch1 in experimental pulmonary hypertension Ralph Schermuly
• Notch-BMPR interactions in endothelium in PAH Marlene Rabinovitch
• Notch3 is a driver and biomarker for PAH Patricia Thistlethwaite 
• Notch3 lineage and pulmonary vasculopathy Maya Kumar 

• A hopeless cause: The pulmonary vasculature is largely gone and irredeemable in PAH, Peter Dorfmüller
• Remnants of lost pulmonary vasculature may be re-engaged in PAH, Duncan Stewart
• Patients with mild pulmonary hypertension (mPAP 21-24) should be treated with PAH approved drugs, David Systrom
• Patients with mild pulmonary hypertension (mPAP 21-24) should NOT be treated with PAH approved drugs, Roham Zamanian

• The right ventricle in HFpEF, Marco Guazzi
• Genetic aspects in group2 PH, Mark Toshner 
• Exercise haemodynamics in heart failure: what can we learn from invasive CPET? Gabor Kovacs 
• Systemic consequences and interorgan cross-talk in heart failure and PH, Stephan Rosenkranz
• The natriuretic peptide Clearance receptor selectively causes right ventricular dysfunction in a model of pulmonary hypertension and heart failure with preserved ejection fraction, Vineet Agrawal 
• N-Lysine methyltransferase Smyd2-mediated HIF-1A stabilization plays a protective role in RV hypertrophy, Swathi Veeroju

• Update from the Fleischner Society Task Force for imaging in pulmonary hypertension, Martine Rémy-Jardin
• Molecular imaging of pulmonary vascular disease using microvascular endothelial cell ligands, Jocelyn Dupuis
• MRI to assess pulmonary vascular changes and PH progression, Jens Vogel-Claussen
• Xenon magnetic resonance imaging signatures of PH, Sudarshan Rajagopal 
• Synchrotron-based phase contrast micro-CT imaging of pulmonary vascular disease in human tissue and animal models, Karin Tran-Lundmark