Extracellular vesicles, exposomes & HIV associated PH

Presented at PVRI 2026 Congress by Navneet Dhillon, University of Kansas Medical Center

Summary

Extracellular vesicles play a significant role in pulmonary vascular remodeling associated with HIV and drug use. HIV-related PH is prevalent, particularly among intravenous drug users. Viral proteins and drugs lead to endothelial dysfunction and smooth muscle proliferation. These vesicles carry microRNAs and proteins that may serve as biomarkers for PH in HIV patients, highlighting the importance of TGF beta signalling and the need for further research.

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