N-Ras: a novel player in endothelial & T cell pathophysiology in PH?

Presented at PVRI 2026 Congress by Edgar Fernández-Malavé, Universidad Complutense De Madrid

Summary

RAs proteins, especially Aras, play crucial roles in biological processes like signaling pathways and T cell responses. Differences in RAs isoforms affect immune responses, with RAs deficiency linked to various disease models. Research shows that RAs deficiency can increase IL-17 production but may also offer protective effects in some contexts. Ongoing studies focus on RAs' influence on vascular remodelling and immune cell dynamics.

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